Two Sandwich Shops Setting the Bar High on James Island (South Carolina) – Yous Guys and Wisconsin Meat & Cheese

By Mark A Leon

James Island, South Carolina, a vibrant community just outside Charleston, SC, is home to two exceptional sandwich shops that are elevating the Lowcountry’s culinary scene: Yous Guys Sandwich Shop and Wisconsin Meat & Cheese.

Each shop offers a unique twist on classic sandwiches, driven by the passion and creativity of their owners. Whether you’re craving authentic Philly flavors or Midwestern-inspired bites, these spots have something special for everyone.

Yous Guys: A Taste of Philly in the Lowcountry

Nestled at 827 Folly Rd, Yous Guys is the labor of love of Chef Don Strong, a Philadelphia native who has brought his hometown’s iconic flavors to James Island. Don’s dream was to recreate the classic 1950s-style Italian delis he frequented in Philly, and he has succeeded in crafting a menu that pays homage to those traditions.

What Sets Yous Guys Apart

At Yous Guys, authenticity is key. Don bakes fresh bread daily for his sandwiches, ensuring every bite is packed with flavor and freshness. However, customers are advised to arrive early or call ahead (843-779-0145)—when the bread runs out, so do the sandwiches! The shop specializes in Philly cheesesteaks, Italian hoagies, and other Northeast-inspired classics.

Menu Favorites
• Italian Hoagie: A classic combination of Italian meats, sharp provolone, and fresh toppings.
• Chicken Marsala Hoagie: A unique twist on a traditional Italian dish.
• Antipasto Salad: A hearty salad featuring prosciutto, capicola, salami, sharp provolone, and pickled cherry peppers.

For vegetarians, Don offers the Hot Veggie Hoagie, loaded with eggplant, mushrooms, red bell peppers, and Sunday gravy.

Location & Hours
Address: 827 Folly Rd, Charleston, SC 29412
Hours: Wednesday–Saturday, 7 AM–7 PM; Sunday, 10 AM-3 PM. Closed Monday and Tuesday.

Don’s dedication to quality and his warm hospitality have made Yous Guys a beloved spot for locals and visitors alike. Whether you’re a Philly native or just someone who appreciates a great sandwich, this shop is worth the visit.

When you enter this tiny shop, you will find some posters and pictures of Little Stranger, a duo hip hop band that Don’ awakened me to and I must say, became a fan very quickly. On behalf of Don and myself, take a listen to Little Stranger.

Wisconsin Meat & Cheese: Midwestern Comfort in Charleston

Just down the road at 1027 Folly Rd, Casey Diederich and Taylor Ambrosius have created a haven for cheese lovers and sandwich enthusiasts with Wisconsin Meat & Cheese. This shop brings a taste of the Midwest to James Island with its curated selection of over 200 cheeses, 50 meats, and gourmet sandwiches.

What Makes Wisconsin Meat & Cheese Special

Casey and Taylor’s shop is more than just a sandwich spot—it’s an experience. With offerings like charcuterie boards, fried cheese curds, and locally sourced beer pairings, they’ve created a cozy space where customers can relax and indulge. The shop also offers indoor and outdoor seating, making it an ideal spot for lunch or an afternoon snack.

Menu Highlights

• Charcuterie Sammie: Prosciutto, salami, brie cheese, mixed greens, tomato, balsamic glaze on a French baguette.
• Wild Turkey: Honey-roasted turkey with goat cheese and blueberry jam on a baguette.
• Grilled Cheesehead: A gooey combination of Colby and brick cheeses on sourdough bread.

For something heartier, try their bratwurst sandwiches or their signature fried cheese curds—an authentic Midwestern treat that pairs perfectly with one of their craft beers.

Location & Hours

Address: 1027 Folly Rd Ste 2, Charleston, SC 29412
Hours:
• Tuesday–Saturday: 10 AM–7 PM
• Sunday: 11 AM–5 PM
• Closed Mondays

Casey and Taylor’s passion for Midwestern flavors shines through in every dish they serve. Their shop has quickly become a favorite on James Island for its welcoming atmosphere and high-quality offerings.

Why These Shops Stand Out

Both Yous Guys and Wisconsin Meat & Cheese bring something unique to James Island’s food scene. Don Strong’s dedication to Philly authenticity at Yous Guys resonates with anyone craving bold flavors crafted with care. Meanwhile, Casey and Taylor’s focus on Midwestern comfort food at Wisconsin Meat & Cheese provides a refreshing variety for locals seeking something different.
Whether you’re in the mood for a hearty hoagie or an artisanal charcuterie sandwich paired with fried cheese curds, these two shops are setting the standard for sandwiches in the Lowcountry. Make sure to visit both—you won’t leave hungry!

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